• However it has been difficult

  2018-11-12

  

  However, it has been difficult to manipulate Notch signaling for therapeutic purposes in vivo. Non-specific interventions of Notch signal in vivo might result in unexpected adverse effects, because Notch signal exists universally in almost all types of cells. Moreover, effective triggering of Notch

• Acknowledgments We are indebted to the Citomics unit of the

  2018-11-12

  

  Acknowledgments We are indebted to the Citomics unit of the IDIBAPS for technical help. This work was supported by grants from the Spanish Ministry of Economia y CompetitividadBIO2011-30299-C02-02 and from CIDEM-Generalitat de CatalunyaVALTEC09-2-0047. and was developed at the Centro Esther Koplowi

• br Introduction Previously it was thought

  2018-11-12

  

  Introduction Previously, it was thought that the fully developed mammalian central nervous system (CNS) lacks significant regenerative capacity (Ramon, 1928). However, the recent discovery of neural progenitor cells, including neural stem NCT-501 (NSCs), has shown a potential for overcoming this

• br Methods and materials br Results br Discussion Existing m

  2018-11-12

  

  Methods and materials Results Discussion Existing methods for hPSC differentiation to endothelial progenitors require the addition of growth factors and/or xenogenic components, limiting their application for large-scale production and therapeutic applications (Bautch, 2011; Wilson et al.,

• DNA methylation can be passively

  2018-11-12

  

  DNA methylation can be passively lost during DNA replication if it is not maintained by DNA methyltransferases (Chen and Riggs, 2011; Li and Zhang, 2014; Moore et al., 2013; Ooi et al., 2009). Besides passive loss due to DNA replication during cell divisions, DNA methylation can also be subject to a

• br Resource details br We generated

  2018-11-12

  

  Resource details We generated KCL032 clinical grade hESC line following protocols, established previously (Ilic et al., 2012; Stephenson et al., 2012), and now adapted to cGMP conditions. The expression of the pluripotency markers was tested after freeze/thaw cycle (Fig. 1). Differentiation pot

• br Summary The newly developed analyzer Soffron

  2018-11-09

  

  Summary The newly developed analyzer Soffron60 is designed for operation with GESA electron-beam material-treatment facilities [1] and can be used at machines with similar characteristics (∼60 kV, ∼100 A, ∼100 µs, 0.1 T) or even with more energetic beam. The analyzer allows determination of SCR 7

• The combination of colors In single pass

  2018-11-09

  

  The combination of colors. In single-pass CCD scanners the color of the falling light is registered by three photodetecting linear arrays that cannot be absolutely identical due to technological variance and therefore may render a distorted image. Analysis of scanned images The scanner breaks th

• Experiments have revealed that the

  2018-11-09

  

  . Experiments have revealed [31,32] that the dolphin understands new commands issued within artificial sign or sound language systems which use five-word-long sentences and interpreting which requires processing both the semantic and the syntactic rules of the language. These results, in our opinion

• br Acknowledgement br Introduction Evidence has long been ac

  2018-11-09

  

  Acknowledgement Introduction Evidence has long been accumulating about the association between social relationships and health and well-being at all ages (Cornwell & Waite, 2009; House, Landis, & Umberson, 1988; Kawachi & Berkman, 2001; Umberson, Crosnoe, & Reczek, 2010). Among life\'s most in

• Surface characteristics and pore structures of adsorbents ar

  2018-11-09

  

  Surface characteristics and pore structures of adsorbents are the main properties in determining the performance of adsorption, based on equilibrium and rate properties as factors needed for plant design. A high surface area to volume ratio will determine a successful adsorbent as adsorption is a su

• br Methods br Results br Conclusion

  2018-11-09

  

  Methods Results Conclusion Acknowledgements Funding: This work was supported by the Water Research Commission (WRC) of South Africa through the WRC Project No. K5/1717 awarded to Prof Evans M.N. Chirwa of the University of Pretoria. Introduction Lipid productivity (LP) is a critical

• Primary orebodies occur at to m depth having irregular

  2018-11-09

  

  Primary orebodies occur at 150- to >450-m depth, having irregular to elongate lens and vein shapes. Grade control data and exploration drilling define significant concentrations of primary uranium ore around the granite porphyry dikes (Fig. 4; Jiangxi No.264 Geologic Party, 1987). Where they are awa

• GSK 137647 Previous research has shown that c myc

  2018-11-09

  

  Previous research has shown that c-myc acts as a key regulator of hTERT transcription during carcinogenesis via its binding to the E-box (Enhancer Box) and subsequent activation of transcription (Kyo et al., 2008). Therefore, one underlying mechanism for MEHP contribution to telomere length maintena

• While most HIV infected individuals develop nAbs against

  2018-11-09

  

  While most HIV-1 infected individuals develop nAbs against their circulating variants and viruses escape this humoral pressure, there are potentially two important factors that explain why CXCR4-using variants do not evolve in everyone. First, CXCR4-utilizing viruses will not emerge if the circulati

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