• In comparison to the standard HPLC

  2022-02-26

  

  In comparison to the standard HPLC assay to detect LPV above or below 1,000 ng mL-1, the accuracy of the PIs-IC strip was 97.8 %, the sensitivity was 100% and the specificity was 97.1 %. This suggests that the PIs-IC strip test has the potential accurately to semi-quantify PI concentrations in plasm

• The glycolytic activator phosphofructo kinase fructose bisph

  2022-02-26

  

  The glycolytic activator 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase 3 (PFKFB3) is well-known as a downstream substrate of hypoxia-inducible factor 1α (HIF-1α) signaling pathway [5,6]. Tumor hypoxia has long been associated with increased malignancy, poor prognosis and drug resistance. HIF-

• In first wave first generation drugs

  2022-02-25

  

  In 2013, first-wave, first-generation drugs telaprevir and boceprevir was the first protease inhibitors (PIs) incorporated in Brazilian Clinical Guidelines for the treatment of patients infected with HCV N6-methyladenosine 1. Based on this 2013 Clinical Guideline, telaprevir could be used for both

• Over the last years numerous studies gave insights into

  2022-02-25

  

  Over the last 15 years, numerous studies gave insights into sGC activation and binding of activators: Photoaffinity labelling studies with cinaciguat suggested the N-terminus of the β1 subunit as target region for this new drug [17]. Schmidt et al. identified the amino acids tyrosine 135, serine 137

• imatinib mesylate In normal tissues the expression

  2022-02-25

  

  In normal tissues, the expression patterns of GPR120 and GPR40 are not uniform. GPR120 is highly expressed in adipocytes, lung and intestinal tract, while GPR40 is shown to be expressed in pancreatic islet imatinib mesylate and intestinal tract [7], [20]. It is considered that the distribution of t

• The GLU Epac transgenic mouse

  2022-02-25

  

  The GLU-Epac transgenic mouse enabled us to monitor cAMP responses to GPR119 ligands in individual primary cultured L-cells. Not all L-cells were found to be responsive to AR231453, suggesting there may be a subpopulation of L-cells that do not express functional GPR119. There was a tendency for sma

• br RNA preparation cDNA synthesis and RT PCR

  2022-02-25

  

  RNA preparation, cDNA synthesis and RT-PCR Trizol reagent (Invitrogen, Carlsbad, CA, USA) was used to extract total RNA from tissues according to the manufacturer’s protocol and isolated RNA quantity was determined by UV spectrophotometry (Nanodrop, Thermo Scientific, USA) and RNA integrity was v

• Elimination of the Q R bridge significantly

  2022-02-25

  

  Elimination of the Q234–R244 bridge significantly affected the protein IOX4 australia but had little effect on its activity at a permissive temperature, which may seem contrary to the known functional importance of this motif in Fpg. However, since the mutants fully or partially retained the bound z

• An increased sympathetic tone and

  2022-02-25

  

  An increased sympathetic tone and the hormone glucagon are the main glucose mobilizing factors [28], [29]. Single-cell transcriptome analysis of human islet cells suggests the expression of Ffar1 not only in β-cells but also in α-cells [30]. Moreover, analysis of rat α-cells indicates that FFAR1 exp

• dapagliflozin br Conclusions We have shown that despite the

  2022-02-25

  

  Conclusions We have shown that despite the development of severe insulin intolerance and marked alterations in whole body substrate oxidation that Gcgr−/− mice are protected against olanzapine-induced hyperglycemia. Our data provides evidence that this protective effect is likely due in large par

• The caseins are a family of

  2022-02-25

  

  The caseins are a family of milk phosphoproteins whose biological function is to provide supersaturating concentrations of calcium, phosphates, and essential Telatinib sale to the neonate (Vonderhaar and Ziska, 1989). α- and β-caseins, the most abundant of the milk caseins, are described as calcium

• It is important to underline

  2022-02-25

  

  It is important to underline that Betaine receptor although ghrelin increases the motivation to eat even in fed state, its effects on food intake and reward are blunted in obese animal models (Zigman et al., 2016). This emphasizes also the interconnection between homeostatic regulation of food inta

• The overall very satisfactory potency

  2022-02-24

  

  The overall very satisfactory potency profile of compounds 7a–l suggests that 1,3,4-thiadiazole-2-carboxamide moiety was a suitable periphery group to add to the 3-phenylpropanoic P7C3 core in order to improve affinity to FFA1. The agonist activity in this series appears to be particularly sensitiv

• br Methods br Results It is well known that

  2022-02-24

  

  Methods Results It is well known that during the onset of vasoconstriction there is an increase in intracellular Ca2+ which activates myosin light-chain kinase followed by cycling of actin-myosin cross-bridges in VSMCs. Recently, it has been recognized that phorbol myristate acetate polymeriz

• Whether ferroptosis specific inhibitor could promotes spinal

  2022-02-24

  

  Whether ferroptosis specific inhibitor could promotes spinal cord repair is a question worth to explore. A potent and stable ferroptosis specific inhibitor is essential for in vivo study. Ferrostatin-1 (Fer-1), the first generation of ferroptosis inhibitor, was shown actively suppressing ferroptosis

16838 records 524/1123 page Previous Next First page 上5页 521522523524525 下5页 Last page