• We also intended to determine the possible mechanism underly

  2021-11-15

  

  We also intended to determine the possible mechanism underlying EZH2 upregulation in the PC. Although no recurrent mutations of EZH2 have been described in CLL [27, 28, 29], we aimed to rule out the possibility of activating mutations in the background of EZH2 overexpression. We detected no mutation

• br Results and discussion Computer modelling

  2021-11-15

  

  Results and discussion Computer modelling studies suggested that the endocyclic oxygens in furocoumarin derivatives, such as phosphodiesterase inhibitors 3a (Fig. 1), could also coordinate metal ions in the HIV-1 IN enzyme active site and inhibit the integration of viral DNA. The coumarin moiety

• Management of HIV treatment with HIV PIs can be complicated

  2021-11-15

  

  Management of HIV-1 treatment with HIV PIs can be complicated due to wide inter-patient variability in MRT67307 HCl levels. In certain scenarios, therapeutic drug monitoring (TDM) has been recommended as a useful approach to individualize therapy for HIV-infected patients [[9], [10], [11], [12]]. Se

• Our results show furthermore that

  2021-11-15

  

  Our results show furthermore, that higher concentrations of butyric WY-14643 additionally affect GSTP1 mRNA stability leading to a strongly reduced half-life. Concentration-dependent effects of butyric acid on RNA stability and cell signaling pathways involved in the regulation of GSTP1 expression r

• Importance of glucokinase in glucose homeostasis and

  2021-11-12

  

  Importance of glucokinase in glucose homeostasis and a possibility to change its activity using the activators define the scientific interest in the development of new allosteric activators of GK (Liu et al., 2012, Pfefferkorn et al., 2011, Waring et al., 2013, Behera et al., 2015). Activation of gl

• Interestingly GAL has also been shown to be co expressed

  2021-11-12

  

  Interestingly, GAL has also been shown to be co-expressed and/or secreted in luteinizing hormone releasing hormone (LHRH) (Merchenthaler et al., 1991, Marks et al., 1994) and kisspeptin (KISS) neurons (Porteous et al., 2011). Furthermore, GAL was shown to stimulate luteinizing hormone (LH) secretion

• br FXR expression in normal intestine and

  2021-11-12

  

  FXR xanthine oxidase in normal intestine and cancer Of note, there are several question marks about FXR post-translational modifications (such as acetylation or SUMOylation) and their involvement in the pathogenesis of metabolic and inflammatory disease (Balasubramaniyan et al., 2013, Kemper et a

• Previous research has suggested that differences in

  2021-11-12

  

  Previous research has suggested that differences in spatiotemporal regulation of intracellular signaling pathways can confer specificity to cellular responses (Marshall, 1995). Conventional approaches based on gain- or loss-of-function genetic manipulations or small-molecule inhibitors, however, lac

• The Hippo pathway is a growth control

  2021-11-12

  

  The Hippo pathway is a growth control signaling cascade that has been demonstrated to play an important role in regulating cell proliferation and differentiation [5,6]. The core signaling pathway consists of a group of kinases which negatively regulate the expression of transcriptional co-activators

• A number of studies have reported that lncRNA may

  2021-11-12

  

  A number of studies have reported that lncRNA may function as sponge to interact with miRNAs at posttranscriptional level, thereby regulating miRNA targeted genes (Tang et al., 2015, Han et al., 2015). For example, lncRNA Malat1 induces autophagy by regulating ULK2 via sponging miR-26b (Li et al.,

• It has been reported that CD glioma

  2021-11-12

  

  It has been reported that CD133+ glioma stem Fmoc-Gly-OPfp sale are resistant to temozolomide (TMZ) therapy [155]. Dose dependent TMZ treatment of CD133+ cells enhanced activities of the Notch and SHh pathways [156]. Moreover, 500 μmol/L TMZ induced a significant upregulation of Gli1, HES1 and HES5

• Compound containing dimethylglutarimide P cap P propyl group

  2021-11-12

  

  Compound containing, dimethylglutarimide P-cap, P propyl group, α-methylbenzyl urea resulted in inhibitor with much improved binding (=0.064μM) and EC=0.3μM. This was an aza-peptide analog with an EC comparable to our first generation clinical candidate . Analog was evaluated for its selectivity

• Using embelin and its analogs as surrogate GPR agonists we

  2021-11-11

  

  Using embelin and its analogs as surrogate GPR84 agonists we discovered that GPR84 couples to G12 and G13 signaling pathways in addition to Gi, linking receptor function to Rho/Rac signaling and modulation of the cytoskeleton. In primary human macrophages, GPR84 activation leads to Gβγ signaling, Er

• Materials and Methods br Results

  2021-11-11

  

  Materials and Methods Results Discussion Activation of TLRs by damage-associated patterns is a well-recognized trigger for inflammation. TLR ligation results in a large increase in glycolytic metabolism in macrophages and other immune cells,12, 27 and we hypothesized that the glycolytic metab

• The ability of FFA to elevate intracellular

  2021-11-11

  

  The ability of FFA4 to elevate intracellular levels of Ca2+5, 38, 39, 40 provided early predictions of a key role of the phosphoinositidase C-linked G proteins Gq and/or G11 in transduction of signals from this receptor, while later studies that examined production of inositol phosphates [41] provid

16689 records 575/1113 page Previous Next First page 上5页 571572573574575 下5页 Last page