• CTGF is an established YAP

  2021-10-27

  

  CTGF is an established YAP/TAZ target gene which plays a central role in tissue remodeling. Downregulation of CTGF mediates collagen loss in chronologically-aged human skin whereas persistent activation of CTGF can result in excessive deposition of collagen and fibrotic disorders [63]. The authors f

• Two distinct mechanisms have been described for

  2021-10-27

  

  Two distinct mechanisms have been described for niacin’s macrophage-based actions [21,22]. First, niacin blocks recruitment of macrophages to atherosclerotic lesions. Second, niacin upregulates macrophage ABCA1 and ABCG1, transporters involved in reverse cholesterol transport. Upregulation of choles

• (-)-Bicuculline methobromide Up to now many UDG assays have

  2021-10-27

  

  Up to now, many UDG assays have been reported based on the design of dU-containing substrate DNA, which can be roughly divided into two categories according to the sensing mechanisms. One type of UDG assays are simply based on the physical or chemical property changes of the substrate accompanied wi

• br Future perspectives A plethora of

  2021-10-27

  

  Future perspectives A plethora of reports from in vivo and in vitro human and animal studies have demonstrated the potential role of FGFR signalling in human carcinogenesis, whether it be in an oncogenic or tumour suppressive capacity. It is still not well understood how FGFRs can act as tumour s

• Remarkably most of these molecules

  2021-10-27

  

  Remarkably, most of these molecules are also quite effective in interfering with the proliferation of the drug-resistant cancer cell lines, with IC50 values ranging from 0.59 to 2.93 μM against MCF-7/ADR cells, and from 0.160 to 1.17 μM against NSCLC-resistant H1975 cells. Among these molecules, com

• br Materials and methods br Results and discussion

  2021-10-27

  

  Materials and methods Results and discussion Conclusion The as-designed system was based on the assembly of MSN-Cy and TPGS, which was dominated by π-π stacking interactions. By the strong mutual force, Cypate and TPGS formed a compact layer around the MSN core, which blocked the drug leaka

• br Memories can last a lifetime long

  2021-10-27

  

  Memories can last a lifetime, long after the transient events have passed. The fact that information stored in the n acetylneuraminic acid receptor can outlast the environmental trigger implies that enduring cellular changes in the central nervous system underlie memory. Epigenetic modifications

• br Methods br Involvement of

  2021-10-26

  

  Methods Involvement of HO-1 in rheumatic diseases Therapeutic strategy targeted HO-1 Based on the researches focusing on the effect of HO-1 in rheumatic diseases, amount of approaches targeting regulation of HO-1 have been arising (See Table 1 for summary). It has been shown that different

• br Introduction The replacement of a regular intake of healt

  2021-10-26

  

  Introduction The replacement of a regular intake of healthy oils and fibres for a diet based substantially on high fat- and high sugar-content foods has had profound consequences for public health. These changes in the way that the populations of high income, particularly Western countries, manag

• PU-WS13 Cichlasoma dimerus as most teleost fish species pres

  2021-10-26

  

  Cichlasoma dimerus, as most teleost fish species, present neurons expressing GnRH3 (Pandolfi et al., 2005). As in most PU-WS13 species, the neurons expressing GnRH3 are mainly located in the NOR, although few neurons were detected in the olfactory bulb, ventral telencephalon and the POA (González-M

• br Materials and methods br

  2021-10-26

  

  Materials and methods Results Discussion In this study, the supF forward mutation assay showed that 5OHU induced mutations in human cells and that a C→T mutation was the predominant mutation among 5OHU-induced mutations. In addition, the DNA cleavage activity assay revealed that 5OHU was ex

• br Conclusions The whole mRNA sequence of equine HRG

  2021-10-26

  

  Conclusions The whole mRNA sequence of equine HRG was identified. Consequently, we successfully generated recombinant equine HRG. By the Western blot procedure, blood HRG in horses was detected. Acknowledgments Introduction Alzheimer's disease (AD) is a chronic neurological disorder with c

• Conformational changes are observed in the LBDs after ligand

  2021-10-26

  

  Conformational changes are observed in the LBDs after ligand binding, including partial cleft closure for GluN2A and complete cleft closure for GluN1. For GluN2A, additional conformational rearrangements in the protein and ligand may be required before the ligand can be accommodated within lobe 2. F

• br Acknowledgements This work is supported by the

  2021-10-26

  

  Acknowledgements This work is supported by the Cognitive Sciences and Technologies Council of Iran (CSTC, Grant No. 95P31), the Iran National Science Foundation (INSF) and the Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. The authors wish to thank Dr. Ayat Kaeidi for his

• Some of the key aspects of the myofibroblasts biology

  2021-10-26

  

  Some of the key aspects of the myofibroblasts’ biology, including their signaling sensitivity and residual regenerative potential, are shaped by their origin. In this respect, lineage studies on myofibroblast precursors are critical for increasing our understanding of the natural history of fibrosis

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