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Furthermore many intermediate plants did not show
2020-12-08
Furthermore, many intermediate plants did not show additive combinations of parental allozymes, which would be expected in F1 hybrids. The absence of some characteristic parental bands suggests that sexual reproduction has occurred among the hybrid plants. Genetic variations within and among the int
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The data in our manuscript confirm previous
2020-12-08
The data in our manuscript confirm previous data on the origin of CMV-specific T Oligomycin A following TCD alloSCT in CMV seropositive patients transplanted with a CMV seronegative donor (R+D−) and demonstrate that also recipient CMV-specific memory T-cells are able to survive alemtuzumab based TC
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Water inorganic salts sugars lipids nucleic acids and protei
2020-12-08
Water, inorganic salts, sugars, lipids, nucleic acids and proteins are the main basic materials forming the organism. Life activities can be controlled or regulated by a series of complicated and chain-reactive protein–protein interactions. Protein–protein interaction is considered as the bases and
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br Introduction Phosphorus P is an
2020-12-08
Introduction Phosphorus (P) is an important nutrient for plant growth; however, in many regions of the world soils are low in plant-available P (Holford, 1997). Therefore, P fertilisers play an important role in agriculture. Most P fertilisers in current use are derived from phosphate rock; howev
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br Experimental Procedures br Acknowledgments br Bisphenol A
2020-12-07
Experimental Procedures Acknowledgments Bisphenol A (BPA) has been recognized as one of the most potent endocrine disruptors, functioning even at very low doses. Although it is anticipated that HG-10-102-01 mg receptor (ER) would mediate these effects of low-dose BPA, studies revealed that
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br Experimental procedures br Acknowledgments br Introductio
2020-12-07
Experimental procedures Acknowledgments Introduction Receptor tyrosine kinases (RTKs) control many fundamental cellular processes, such as cell proliferation, differentiation, migration, and metabolism (Lemmon and Schlessinger, 2010). RTK activity is normally tightly controlled, and dysregu
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Our study found a significant association
2020-12-07
Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P EGFR phosphodiesterase inhibitor status. However, only a small portion of these previous studies included the evaluation of lobulation, and almost all of them reported no association
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In conclusion we have shown
2020-12-07
In conclusion, we have shown that the cellular effects produced by SFN in NSCLC NU 9056 are largely mediated by SFN-induced production of ROS. Cells with higher levels of EGFR were more resistant to SFN treatment and showed resistance to SFN-induced apoptosis, suggesting that high EGFR levels protec
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br Mass spectrometry based technologies Oxysterols
2020-12-07
Mass spectrometry-based technologies Oxysterols tend not to be observed in global lipidomic analysis, whether shot-gun based electrospray ionisation – mass spectrometry (ESI-MS) or liquid chromatography (LC)-MS based. This is because of their comparatively low-abundance and poor ionisation charac
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Protein deubiquitination is becoming increasingly instrument
2020-12-07
Protein deubiquitination is becoming increasingly instrumental in understanding the complexities of the Ub system. Adding to this complexity is the discovery of bacterial effectors with DUB activity that have structurally adapted themselves to interfere with the eukaryotic Ub system (Pruneda et al.,
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The nuclear receptor related protein Nurr
2020-12-07
The nuclear receptor related-1 protein, Nurr1 (NR4A2), is a transcription factor that regulates the b 35 of genes critical for the development, maintenance, and survival of dopaminergic neurons (Alavian et al., 2014, Decressac et al., 2013, Dong et al., 2016, Jankovic et al., 2005, Johnson et al.,
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More recently Boskovic et al have visually corroborated
2020-12-07
More recently, Boskovic et al. (2003) have visually corroborated that purified DNA-PKcs can bind short DNA fragments by using single particle EM. DNA biotinylated at the 5′ end was labelled by coupling to commercial streptavidin–gold particles (Fig. 4D). When analysed in the microscope, DNA-PKcs mol
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br Materials and methods br Results br Discussion The HT
2020-12-07
Materials and methods Results Discussion The 5-HT2A and D2 receptors have a functional crosstalk (Albizu et al., 2011) and they SM-164 are all richly expressed in the mesolimbic and mesocortical systems (Azmitia and Segal, 1978; McMahon et al., 2001), providing the neuroanatomical basis fo
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br Introduction Coping with DNA damage
2020-12-07
Introduction Coping with DNA damage is possible thanks to surveillance mechanisms (checkpoints), that detect the problem and promote its solution [1], [2], and to repair and tolerance pathways that remove the lesions or reduce the damage consequences [3], [4]. Failures in these processes have a h
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Introduction Psoralea corylifolia L Leguminosae is
2020-12-07
Introduction Psoralea corylifolia L. (Leguminosae) is a well-known traditional Chinese medicine, and it has been widely used for the treatment of various diseases like bronchial asthma, leucopenia, vitiligo and psoriasis in East Asian countries (Zhang et al., 1990). Previous studies have reported t
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