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While lowering the TID exposure
2020-08-21
While lowering the TID exposure of electronics is fairly straightforward, there are other gdc com induced effects that are not as easily mitigated, especially with COTS components. Single Event Effects (SEE) occur when a high-energy particle strikes the active area of an integrated circuit, causing
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Due to its several industrial applications the recombinant p
2020-08-21
Due to its several industrial applications, the recombinant production of collagen and all its derivatives as gelatins has been pursued for many years in different biological systems as mammalian Venlafaxine (Toman et al., 1999), tobacco plants (Ruggiero et al., 2000), silkworms (Tomita et al., 200
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A previous pharmacokinetic study of curcumin
2020-08-20
A previous pharmacokinetic study of curcumin in mice demonstrated that curcumin could not be detected in plasma after a single oral dose of 75 mg/kg of curcumin. After 4-months administration of 75 and 300 mg/kg of curcumin, plasma levels of curcumin and THC were 0.095 and 0.465 μM and 0.025 and 0.1
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chenodeoxycholic acid WES and validation by Sanger sequencin
2020-08-20
WES and validation by Sanger sequencing in PNGS-252 revealed an apparent homozygous c.4C>G missense alteration (GenBank: NM_014176.3), resulting in the amino chenodeoxycholic acid substitution p.Gln2Glu (Figure 1A). This mutation must be very rare, because this is not listed in the NHLBI Exome Sequ
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In the gel shown in Figure
2020-08-20
In the gel shown in Figure 8, at early time-points, 14% of the input dsDNA is converted to these intermediate species. These persist in the gel to later times, with approximately 50% of these being unwound. This unwinding occurs at a considerably slower rate and is due to that fraction of the popula
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Some pyrimidine analogs are substrate based inhibitors that
2020-08-20
Some pyrimidine analogs are substrate-based inhibitors that bind to the dihydroorotate binding site, but most reported inhibitors of DHODH bind to the site occupied by the ubiquinone co-factor., , , , , , , , , , , , , , , , , X-ray crystallographic studies of inhibitor complexes with DHODH and DHO
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Introduction Rotavirus RV a member of
2020-08-20
Introduction Rotavirus (RV), a member of Reoviridae family, is a non-enveloped virus which has a double-stranded RNA genome of 11 segments surrounded by three concentric protein layers. It has been reported to cause estimated 25% of moderate-to-severe illnesses (Kotloff et al., 2013) and 30% of tot
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Recent data obtained with etifoxine suggest that
2020-08-20
Recent data obtained with etifoxine suggest that facilitation of GABAergic inhibition may be also associated with an indirect mechanism implying activation of the peripheral benzodiazepine receptor with a subsequent increase in neurosteroid production (Schlichter et al., 2000, Verleye et al., 2005).
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Bicalutamide Prostaglandins production and some of their pos
2020-08-20
Prostaglandins production and some of their possible biological functions have been reported in protozoa, helminths, and fungi organisms, for example amphizoic amoebas of the genus Acanthamoeba and Entamoeba (E. histolytica) produce PGA2, PGE2 and PGF2α [5,6]. PGA2 is believed to be an intrinsic osm
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MMP-2 Inhibitor I In we studied normal rational varieties X
2020-08-20
In [1] we studied normal, rational -varieties X of complexity one, where the latter means that X comes with an effective torus action such that holds. We showed that for affine X with and at most log terminal singularities, the iteration of Cox rings is possible. In the present article, we charac
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br Methodology The following subsections describe the
2020-08-20
Methodology The following subsections describe the steps of the Systematic Literature Review (SLR) process we followed [9]. Results In our review of the literature, we used the definitions provided by the IEEE Standard Computer Dictionary [15] to categorize the claims about the effectiveness
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The Fontan circulation When first described in the Fontan op
2020-08-20
The Fontan circulation When first described in 1971, the Fontan operation ushered in a new paradigm in the care of children born with the varied forms of complex congenital 3X FLAG disease (CHD) characterized by a single effective pumping chamber.1., 2. This procedure, which creates a total cavopu
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A large fraction of UCEs are transcribed T
2020-08-20
A large fraction of UCEs are transcribed (T-UCEs) in a tissue specific manner, and are deregulated in several human cancers (Calin et al., 2007, Fabbri et al., 2008, Fassan et al., 2014, Olivieri et al., 2016). Indeed, it has been shown that T-UCEs may also act as long non-coding RNAs (lncRNAs) regu
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Studies of nuclear transplantation of diploid imprint free
2020-08-20
Studies of nuclear transplantation of diploid imprint-free PGCs have shown that the reconstituted oocytes developed to day 9.5 of gestation, with severely retarded embryos and abnormal placentae (Kato et al., 1999). We also reported that MII oocyte injection of imprint-free phESCs without imprinted
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Dehydrocostus Lactone australia With the recent expanse of t
2020-08-19
With the recent expanse of technology to evaluate synthetic lethality, new combinations with DHODH inhibitors may be uncovered (O\'Neil, Bailey, & Hieter, 2017). Many oncogenic backgrounds share synthetic lethality with DHODH. Cells with mutant PTEN have increased glutamine metabolism and are sensit
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