• The reported increased long chain fatty acid oxidation LC

  2020-08-03

  

  The reported increased long-chain fatty Agar receptor oxidation (LC-FAO) in those cells can certainly aid OXPHOS, but studies interrogating the functional importance of LC-FAO to support M(IL-4) phenotypes have yielded conflicting results (Van den Bossche et al., 2017). The need for increased LC-FA

• Any consideration of RING type E s must include their

  2020-08-03

  

  Any consideration of RING-type E3s must include their partners, the E2s. E2s have a core conserved ubiquitin-conjugating (UBC) domain that contains a conserved catalytic Cys (Fig. 2). Some E2s have insertions within the UBC domain or N- or C-terminal extensions that confer specific functions. For HE

• It was hypothesized that if modafinil acts primarily via

  2020-08-03

  

  It was hypothesized that if modafinil acts primarily via a noradrenergic mechanism, Dbh −/− mice should be non-responsive since they completely lack NE. In contrast, if modafinil acts mainly through DA systems, these mice should be hypersensitive. Modafinil was tested in Dbh −/− mice using both loco

• In Pakistan rice is considered as one of

  2020-08-03

  

  In Pakistan, rice is considered as one of the cash crop and about 6 million tonnes of good quality rice produce every year [33]. From the report of researchers, it is concluded that 20% of rice paddy is husk, it means that Pakistan produces nearly 1.2 million tonnes of rice husk every year. Out of 6

• Recombinant Leishmania antigens have been evaluated as

  2020-08-03

  

  Recombinant Leishmania antigens have been evaluated as new diagnostic tools for VL. Fonseca et al. (2014) showed that the recombinant C9 protein presented an accuracy of 0.79, with specificity and sensitivity values of 80% and 70%, respectively, for the serodiagnosis of human VL. Oliveira et al. (20

• Orthologues of carotenoid dioxygenases used by humans

  2020-08-03

  

  Orthologues of carotenoid dioxygenases, used by humans to produce retinal from beta-carotene, have previously been characterised from the cyanobacteria Synechocystis PCC 6803 and Nostoc PCC 7107 [[11], [12], [13], [14]]. These orthologues are able to convert beta-carotene and apo-8-carotenal into al

• Furthermore our sample preparation uses a

  2020-07-31

  

  Furthermore, our sample preparation uses a simple isolation procedure. Numerous CYP450 phenotyping methods employed extensive extraction procedures for sample preparation such as dual liquid extraction or solid phase extraction which are costly and time consuming [10], [17], [18], [19], [20], [23],

• In this study we have used a mouse model of

  2020-07-31

  

  In this study we have used a mouse model of post-incisional pain that closely mimics the surgical procedure in humans in order to evaluate the role of CRF/CRF1 receptors in the pro-nociceptive and inflammatory response to injury (incision), using genetically engineered mice lacking functional CRF1 r

• We have recently reported in

  2020-07-31

  

  We have recently reported in a partially overlapping series that tumors with EWS-ERG fusions have a similar clinical presentation and behavior as those with EWS-FLI1 chimeric genes. It may thus be unexpected that there was a difference in proliferative index, as assessed by Ki-67 immunoreactivity, b

• Enolase is of particular interest since it

  2020-07-31

  

  Enolase is of particular interest since it may influence the pathogenic process by three different routes: as a cell surface protein, as a component of the RNA degradosome or as an enzyme. In gram-positive bacteria enolase is found on cell surfaces and binds to laminin, fibronectin, and collagens (a

• The CD cysteine protease of S mansoni Sm also

  2020-07-31

  

  The CD13 cysteine protease of S. mansoni (Sm32, also known as SmAE or schistosome legumain) is an asparaginyl endopeptidase (AE) that cleaves C-terminal to asparaginyl (Asn) residues (Dalton et al., 2009). This protein has been characterized, cloned and sequenced (Klinkert et al., 1989; Davis et al.

• The number of leukocytes in the

  2020-07-31

  

  The number of leukocytes in the bronchoalveolar lavage and the total number of macrophages and neutrophils in the alveolar space of the PPE 64d group was higher than that in the control group. Jiang et al. [29] investigated the role of the serotonin (5-HT or 5-HTT) transporter and the effect of sim

• Alternation of joints by mechanical stress produces microcra

  2020-07-31

  

  Alternation of joints by mechanical stress produces microcracks and deterioration of natural pores in subchondral bone provides Mupirocin for cross talk through diffusion of small molecules [26,27]. At early stage of OA, chondrocytes in the injured cartilage releases transforming growth factor beta

• erk inhibitors How does APC C recognize its substrates

  2020-07-31

  

  How does APC/C recognize its substrates and catalyze their ubiquitylation? How are the outcomes and timing of these activities regulated? These questions have driven a decade of structural studies that begin to explain how APC/C interacts with coactivators, substrates, and E2s, and how these interac

• Historically covalent drugs have had great success e

  2020-07-31

  

  Historically, covalent drugs have had great success (e.g., aspirin and penicillin), and covalent drugs have become a focus in anticancer and antiviral drug discovery (Kalgutkar and Dalvie, 2012, Singh et al., 2011). These compounds contain low reactivity warheads that allow covalent adducts to form

15999 records 796/1067 page Previous Next First page 上5页 796797798799800 下5页 Last page