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br RING dimerization RING type domains are found in
2019-09-04
RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain chir99021 (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF4, BIRC7 (sh
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br UVC induced DNA damage a
2019-09-04
UVC-induced DNA damage: a model to study DNA damage tolerance The UV components of sunlight that reaches the Earth surface are one of the most carcinogenic agents humans are exposed to, and the leading cause of skin cancer [4,12]. UV light causes different types of DNA damage through indirect and
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The fibrillogenesis process of collagen is understood to ini
2019-09-04
The fibrillogenesis process of collagen is understood to initiate in the extracellular space near the plasma membrane where secretory vesicles form regions of deep invagination. However, it is not clear how and when collagen-binding proteins interact with collagen molecules during fibrillogenesis or
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ubiquitin conjugating enzyme br Crystal structure of c
2019-09-04
Crystal structure of c-FMS and binding pattern of CSF-1 and IL-34 c-FMS is a 972 amino acids polypeptides containing transmembrane glycoprotein [19]. It contains all the necessary domains required for tyrosine kinase activity, i.e. 512 amino ubiquitin conjugating enzyme N-terminal extracellular
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br Methods Adult male B CRHtklee mice g at the
2019-09-04
Methods Adult male B6, 129 CRHtklee mice (25–30g at the beginning of the experiments) that were wild-type (CRF1R+/+) and recessive homozygous or knockout (CRF1R−/−) were housed six per cage. Mice were 3–5months old and derived from mating CRF1R+/− breeders (Jackson Laboratory, California). Wild-t
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The enzymatic activity of recombinant sponge P H was assayed
2019-09-04
The enzymatic activity of recombinant sponge P4H was assayed in vitro both at 37°C, the standard enzymatic kinetics temperature, and at 15°C, the typical sea temperature of C. reniformis marine environment (Fig. 2C). Surprisingly the data obtained indicate that the sponge enzyme has a lower activity
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br Materials and methods br
2019-09-04
Materials and methods Results Discussion Neointimal VSMC accumulation contributes considerably to vessel occlusion observed in both autologous vein graft degeneration [1], [2] and in-stent restenosis [26], [27]. In this study, the potential for retarding VSMC proliferation and hence amelior
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The repeat sequence TTAGGG of
2019-09-04
The repeat sequence “TTAGGG” of telomere could be directly recognized by TERF1. TERF1 is indispensable for the maintenance of telomere Thonzonium Bromide clinical structure and integrity (Tan et al., 2017). Trf1 genetic depletion in vivo induces a persistent DNA damage response and telomere uncappin
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br Use of CDK inhibitors in CLL today There
2019-09-03
Use of CDK inhibitors in CLL today There has been explosive development of novel therapeutics for CLL in the last decade and a massive transformation of practice is underway [75]. Most of this development and excitement revolves around B-cell receptor (BCR) signaling inhibitors: the Bruton tyrosi
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Acidic substituents showed moderate biochemical activity but
2019-09-03
Acidic substituents () showed moderate biochemical activity, but these compounds showed reduced cellular potency. Additional compounds bearing a carboxylic Z-VEID-FMK clinical were also prepared and tested (data not shown). All of acidic compounds showed low cellular potency regardless of their bio
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Besides the regulation of the
2019-09-03
Besides the regulation of the stress responses, CRF and the urocortins have been implicated in drug addiction (Bruijnzeel and Gold, 2005, Sarnyai et al., 2001). For instance nicotine, the addictive substance of tobacco, can activate the HPA axis, just like any other stressor may do, although its imp
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The aim of the present study
2019-09-03
The aim of the present study was to investigate the acute effects of THC on resting state BKM120 neurophysiology, and to examine the impact of COMT genotype on these effects. Thirty-nine healthy volunteers participated in a randomised, placebo-controlled, crossover pharmacological MRI study. Acute e
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Materials and methods br Results br
2019-09-03
Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino Anisomycin for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with the existing
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ache inhibitor br Acknowledgements br Introduction Water and
2019-09-03
Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and ache inhibitor governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of channel proteins in cancer ce
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br Introduction Myotonic dystrophy dystrophia myotonica DM i
2019-09-03
Introduction Myotonic dystrophy (dystrophia myotonica, DM) is an autosomal dominant disorder and the most common form of inherited muscular dystrophy in adults [1]. DM is characterised by a wide range of symptoms, including myotonia, progressive muscle loss, cataracts, cardiac conduction defects,
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