• Whyte added that information management has a strong relatio

  2018-11-12

  

  Whyte (2011) added that information management has a strong relationship with project management, suggesting that (1) new digital tools and processes increase the coupling between the various disciplines involved in design, implying wider organizational changes across firm boundaries, and (2) the pr

• Many Muslims have established new homes in different locatio

  2018-11-12

  

  Many Muslims have established new homes in different locations across the globe in recent years. Islam involves strong religious traditions that apply directly to the structure and organization of life within the home and its environment. Within the Islamic faith, a home is considered to be a “micro

• oleuropein br Materials and methods br Statistical analysis

  2018-11-12

  

  Materials and methods Statistical analysis The statistical end point of the analyses was the disease-free survival (DFS) from the date of surgery. Group distributions for each clinicopathologic trait were compared using two-tailed Fisher\'s exact procedure and the chi-square test. Numerical va

• Malignant tumors in solid and bowel organs were

  2018-11-12

  

  Malignant tumors in solid and bowel organs were different with regard to tumor spreading or in tumorigenesis. Distal bowel intramural spread is present within 1 cm distally from the visible tumor in a substantial proportion of patients. For these reasons, for patients with low-lying cancer who are u

• Associated hyperostosis of the anterior skull

  2018-11-12

  

  Associated hyperostosis of the anterior skull azidothymidine manufacturer is extremely rare for patients with ENBs. Meningioma-associated hyperostosis is relatively common, generally localized, and proportional to the tumor size; the potential pathogenesis of tumor-associated hyperostosis was consi

• br Concluding remarks Overall the achievements in food toxic

  2018-11-12

  

  Concluding remarks Overall, the achievements in food toxicology in the last decades have been significant gaining a deeper understanding of the molecular mode of action by which toxic effects are induced. These mechanistic insights have helped to identify potential toxicants thus enhancing food s

• To explain this effect of GAG mimetics on bone regeneration

  2018-11-12

  

  To explain this effect of GAG mimetics on bone regeneration, we hypothesize that it is partly due to their capacity to modulate endogenous MSC properties in vivo. Therefore, to validate this Baricitinib cost we investigated in this study whether some particular mimetics are able to potentiate effec

• br Results br Discussion Despite the widespread clinical use

  2018-11-12

  

  Results Discussion Despite the widespread clinical use of hMSCs, there are fundamental gaps in our knowledge of basic MSC biology. In contrast to HSCs, the molecular mechanisms that maintain MSCs in their undifferentiated state or determine their differentiation pathways are still poorly under

• However it has been difficult

  2018-11-12

  

  However, it has been difficult to manipulate Notch signaling for therapeutic purposes in vivo. Non-specific interventions of Notch signal in vivo might result in unexpected adverse effects, because Notch signal exists universally in almost all types of cells. Moreover, effective triggering of Notch

• Acknowledgments We are indebted to the Citomics unit of the

  2018-11-12

  

  Acknowledgments We are indebted to the Citomics unit of the IDIBAPS for technical help. This work was supported by grants from the Spanish Ministry of Economia y CompetitividadBIO2011-30299-C02-02 and from CIDEM-Generalitat de CatalunyaVALTEC09-2-0047. and was developed at the Centro Esther Koplowi

• br Introduction Previously it was thought

  2018-11-12

  

  Introduction Previously, it was thought that the fully developed mammalian central nervous system (CNS) lacks significant regenerative capacity (Ramon, 1928). However, the recent discovery of neural progenitor cells, including neural stem NCT-501 (NSCs), has shown a potential for overcoming this

• br Methods and materials br Results br Discussion Existing m

  2018-11-12

  

  Methods and materials Results Discussion Existing methods for hPSC differentiation to endothelial progenitors require the addition of growth factors and/or xenogenic components, limiting their application for large-scale production and therapeutic applications (Bautch, 2011; Wilson et al.,

• DNA methylation can be passively

  2018-11-12

  

  DNA methylation can be passively lost during DNA replication if it is not maintained by DNA methyltransferases (Chen and Riggs, 2011; Li and Zhang, 2014; Moore et al., 2013; Ooi et al., 2009). Besides passive loss due to DNA replication during cell divisions, DNA methylation can also be subject to a

• br Resource details br We generated

  2018-11-12

  

  Resource details We generated KCL032 clinical grade hESC line following protocols, established previously (Ilic et al., 2012; Stephenson et al., 2012), and now adapted to cGMP conditions. The expression of the pluripotency markers was tested after freeze/thaw cycle (Fig. 1). Differentiation pot

• br Summary The newly developed analyzer Soffron

  2018-11-09

  

  Summary The newly developed analyzer Soffron60 is designed for operation with GESA electron-beam material-treatment facilities [1] and can be used at machines with similar characteristics (∼60 kV, ∼100 A, ∼100 µs, 0.1 T) or even with more energetic beam. The analyzer allows determination of SCR 7

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