• In this research the definition of rhythm how

  2018-10-31

  

  In this research, the definition of rhythm, how it is created, and why it is a part of human design cognition are explored through case studies. Even though rhythm is seen as a phenomenon, it has not been approached from a phenomenological point of view on what thing (i.e., rhythm) means (Brentano,

• Introduction Cancer related fatigue CRF is a common health c

  2018-10-31

  

  Introduction Cancer-related fatigue (CRF) is a common health concern among cancer survivors and patients with cancer; however, the mechanisms underlying the development and persistence of this symptom remain unclear. An overactivation of the mth1 inhibitor may induce CRF, which is mediated by proi

• Previous MCAO studies of MHP cells

  2018-10-31

  

  Previous MCAO studies of MHP36 glucocorticoid receptor antagonist have used rats and assessed functional recovery using behavioural tasks (e.g. neurological severity score, rotational bias, spontaneous activity, bilateral asymmetry test, water maze). Improvement within six weeks after administratio

• corticotropin releasing factor We also determined the safety

  2018-10-31

  

  We also determined the safety of transplanting incompletely differentiated iPS cells. It has been demonstrated that iPS-CMs are safe after transplantation into the heart, but their proliferation is limited (Nelson et al., 2009). Therefore, the selection of adequate time points during differentiation

• cam kinase ii A microsatellite PCR profile has been

  2018-10-31

  

  A microsatellite PCR profile has been obtained for the cell line, and HLA Class I and II typing is available (Table 1). Blood group genotyping gave the blood group O1O1, expected to give rise to blood group O+ (Table 1). The cell line is free from mycoplasma contamination as determined by RT-qPCR.

• The elevation of JAG surface expression in transitional ECs

  2018-10-31

  

  The elevation of JAG1 surface expression in transitional ECs suggests that it plays a role in phenotypic transition of these cells. Overexpression of activated JAG1 cDNA in cultured human microvascular ECs activated a SMA-promoter driven luciferase and induced trans-differentiation to vascular smoot

• On the path toward induced pluripotency

  2018-10-31

  

  On the path toward induced pluripotency, investigators rely on gene expression patterns as milestones to gauge appropriate progression, and comparative analysis of publically available gene expression profiles is a common approach. Clearly, our data show that inconsistencies in the relative levels o

• br Experimental Procedures Extended details outlining

  2018-10-31

  

  Experimental Procedures Extended details outlining specific steps and protocols can be found in the Supplemental Experimental Procedures. Author Contributions Acknowledgments Introduction Proximal spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by t

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-31

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Unlike the human prostate, which is organized into a single lobe with varying zonal layers, the murine prostate has four distinct lobes surrounding the urethra. The adult prostate contains three epithelial lineages

• br Introduction Visional signals are mediated by

  2018-10-31

  

  Introduction Visional signals are mediated by photoreceptors, bipolar caspofungin and ganglion cells, and the loss of these neurons leads to irreversible blindness (de Jong, 2006; Friedman et al., 2004; Hartong et al., 2006; Quigley and Broman, 2006; Ramsden et al., 2013; Thylefors et al., 1995)

• Introduction Previous studies describing functional

  2018-10-31

  

  Introduction Previous studies describing functional recovery following transplantation of neural stem/progenitor order SAG (NS/PCs) in spinal cord injury (SCI) models demonstrated the therapeutic promise of this approach (Cummings et al., 2005; Iwanami et al., 2005). A number of putative underlying

• In many studies the reprogramming factors

  2018-10-31

  

  In many studies, the reprogramming factors were delivered individually using monocistronic vectors. However, due to differences in vector uptake, expression levels of each gene in each cell are highly variable (Lo et al., 2015). Since the ratio between the factors is one of most critical factors for

• br Methods br Results br Discussion In this

  2018-10-30

  

  Methods Results Discussion In this study, a prevalence value for daytime sleepiness and sleep complaints in airline pilots was established. Regarding fatigue, a high prevalence for this professional group was also observed. The variable ‘type of flight’ had a statistically significant predi

• br Conflict of interest br Acknowledgements Authors would

  2018-10-30

  

  Conflict of interest Acknowledgements Authors would like to thank the financial support of the European Community’s Seventh Framework Programme FP7-SME-2013 “DEMOTOX” – Proposal no 604752, the Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia (Rome, Italy) and the Italian

• Introduction We have recently demonstrated an efficient

  2018-10-30

  

  Introduction We have recently demonstrated an efficient methodology for the synthesis of self assembled monolayers (SAMs) based on thiolated long-chain alkanethiols (LCAT) incorporating oligoethyleneglycol (OEG) linkers of variable length [1]. LCAT-OEGs have been shown to be ideally suited for inte

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