Heat shock proteins as molecular chaperones are involved

2018-10-20

Heat shock proteins, as molecular chaperones, are involved in a variety of cellular functions. Apart from their commonly known roles in maintaining protein stability and mediating the assembly and disassembly of protein complexes, recent studies have shown that certain chaperones, including HSPA8, a

In summary our results revealed

2018-10-20

In summary, our results revealed that loss of Eva1a leads to impaired NSC self-renewal and differentiation, along with a decrease in autophagy, which is inversely associated with the activation of the PIK3CA/AKT-mTOR signaling. Functionally, EVA1A overexpression or MP treatment substantially rescued

amyloid Many SMs have been reported to facilitate reprogramm

2018-10-20

Many SMs have been reported to facilitate reprogramming. For example, sodium butyrate (N, NaB), a histone deacetylase (HDAC) inhibitor, greatly improved reprogramming efficiency by upregulating epigenetic remodeling and pluripotency-associated amyloid (Mali et al., 2010; Zhang and Wu, 2013). In ano

Gene set enrichment analysis GSEA of

2018-10-20

Gene set enrichment analysis (GSEA) of developmentally regulated genes showed that transcripts from bivalent genes were preferentially upregulated in Dicer-deficient ESCs, comparable with a set of Targetscan-predicted target genes of miR-290–295 (Figure 3B). Eight sets of developmental genes were us

Introduction The role of chromatin status on DNA

2018-10-20

Introduction The role of chromatin status on DNA damage response (DDR) and DNA double-strand break (DSB) repair has been extensively investigated in differentiated non-stem and cancer cells. Chromatin structure and remodeling plays an important role in the recruitment/assembly of repair factors and

Hello world!

2018-07-29