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Introduction Heterotrimeric G proteins mediate signal transd
2024-12-27
Introduction Heterotrimeric Gαβγ proteins mediate signal transduction through seven-transmembrane domain receptors. In response to neurotransmitters or hormones, activated receptors bind GTP via the Gα subunit leading to the dissociation of Gα from the Gβγ dimer. G proteins regulate the levels of s
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Interestingly we found that co treatment with losartan preve
2024-12-27
Interestingly, we found that co-treatment with losartan prevented the increased participation of ROS from NADPH oxidase on the contractile response to Phe observed in Hg-treated rats. Moreover, losartan also prevented the reduction in the endothelial NO modulation of this response found in treated a
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br AR signaling and urothelial cancer progression
2024-12-27
AR signaling and urothelial cancer progression As shown in other types of malignancies, such as prostate cancer cells, it has been documented that androgens induce AR expression and its nuclear translocation as well as ARE promoter activity in urothelial cancer cells (Chen et al., 2003, Izumi et
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Akt is another upstream kinase
2024-12-27
Akt is another upstream kinase known to phosphorylate AMPK Ser489 in response to high insulin levels [7], [21]. HepG2 Laminin 925-933 show an increase in phosphorylation of AMPK at Ser485 when incubated with either insulin or troglitazone individually (Fig. 5A and C). Despite this concurrent increa
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Not all secondary metabolites or natural
2024-12-27
Not all secondary metabolites or natural products can be fully synthesized due to their very complex structures that are too difficult and expensive on industrial scale. Hence, there is an urgent need to search for alternative remedies as naturally occurring biologically active secondary metabolites
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3-Hydroxy-1,2,3-benzotriazin-4(3H)-one MAPs require divalent
2024-12-27
MAPs require divalent transition metal ions as cofactors for activity [21]. Previous studies on MAPs from different organisms indicate cobalt ions to be the most preferred divalent metal activator [22]. However, MAPs also exhibit activity with other divalent cations like Mn(II), Ca(II), Ni(II) or Fe
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br Conclusion P gingivalis expresses various
2024-12-27
Conclusion P. gingivalis expresses various exopeptidases, i.e., DPP4, DPP5, DPP7, DPP11, PtpA, and AOP, in periplasmic space, which produce di- and tri-peptides from most oligopeptides. This oligopeptide processing step is important as an extracellular event in the Detergent-compatible protein an
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br Methods br Results br Discussion By
2024-12-27
Methods Results Discussion By following a large cohort of older persons for up to 11 years, we found that subjects with more degraded FR in motor activity (i.e., weaker temporal activity correlations at time scales TRPV1 channel blocker pathologies affect diverse clinical phenotypes and are
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Interestingly all of the ROS rearrangements
2024-12-27
Interestingly, all of the ROS1 rearrangements share a constant breakpoint in ROS1 and the fusion product contain the kinase domain resulting in aberrant ROS1 expression with constitutive kinase activity. Intrachromosomal deletions and interchromosomal translocations have demonstrated the existence o
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Implicit in this concept is the
2024-12-27
Implicit in this concept is the idea that the β-adrenoceptors in the detrusor would be activated by adrenergic nerves of the sympathetic system: sympathetic activity promoting relaxation and enhancing bladder capacity. However, it has been demonstrated that there is only a sparse adrenergic innervat
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ACE inhibition is often thought to play
2024-12-26
ACE inhibition is often thought to play a central role in the mechanisms of blood pressure reduction in vivo, and most ACE inhibitory (ACEi) peptides were characterized based on in vitro ACE inhibition. A relationship between in vitro ACE inhibition and antihypertensive activity, however, is not app
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Casein accounts for of the total protein
2024-12-26
Casein accounts for 80% of the total protein in bovine milk (Capriotti, Cavaliere, Piovesana, Samperi, & Laganà, 2016); hydrolysates or bioactive peptides derived from casein have been employed widely in food as a functional ingredient (Capriotti et al., 2016, Field et al., 2008). Many studies have
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The combination of Aurora kinase inhibitors
2024-12-26
The combination of Aurora kinase inhibitors with standard chemotherapeutics or radiotherapeutics are currently in progress, such as AZD1152 plus radiotherapy in various solid cancer models. In addition, Azzariti et al. found that AZD1152-HQPA enhanced oxaliplatin and gemcitabine effectiveness in the
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Many ruthenium complexes were tested as potential anticancer
2024-12-26
Many ruthenium complexes were tested as potential anticancer agents and two complexes, namely NAMI-A (trans-[imH] [RuCl4(dmso-S)(im)]; im, imidazole) and KP1019 (trans-[indH][RuCl4(ind)2]; ind, indazole) have successfully entered clinical trials [27], [28]. NAMI-A is selectively active against metas
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The canonical binding sites to which
2024-12-26
The canonical A 804598 to which α2, α3, or α5 contribute are highly similar. Therefore, differences in ligand affinity will not be large even if a ligand makes optimal use of the small differences in the pockets. As a possible alternative approach to achieve separation of compound effects, ligands
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